kolblab.org

Kolb Lab Heisenberg DFG

The Kolb Lab is located at the Department of Pharmaceutical Chemistry at Philipps-Universität Marburg.
We are a member lab of SYNMIKRO
and DRUID.



The lab was deeply involved in COST Action CM1207 "GLISTEN: GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network"
and part of SynChemBio.
The lab started through the generous funding provided within the DFG's Emmy Noether Programme. Emmy Noether DFG
[en][de]

Research interests

Docking
Word cloud generated with WordClouds.com from publication abstracts. Thanks to Xavier Deupi for the idea!

Small molecules are frequently used both in Nature and therapeutically to modulate the activity of the protein they bind to. Yet, many aspects of small-molecule:protein interactions are surprisingly poorly understood. For instance, ligand polypharmacology, i.e. binding to multiple proteins, often comes as a surprise, although it is frequently precisely the reason for a drug's efficacy or its side effects. On the protein side, a point mutation in the binding site, although only a small change, can abolish drug binding, leading to resistance. Thus, it is highly relevant to develop a comprehensive understanding of small-molecule:protein interaction profiles in molecular detail and correlate these profiles with signaling and metabolic pathways.

Our main tool is small molecule docking, but we also use chemoinformatic approaches and molecular dynamics. The research spans method development, basic research and applications. Currently the investigations deal with kinases and G protein-coupled receptors (GPCRs).


Publications

Most recent:
38 Nanobody-enabled reverse pharmacology on GPCRs.
Els Pardon, Cecilia Betti, Toon Laeremans, Florent Chevillard, Karel Guillemyn, Peter Kolb, Steven Ballet, Jan Steyaert
Angew. Chem. Int. Ed. 2018, 57, 5292-5295. [pdf]
37 Binding-site compatible fragment growing applied to the design of β2-adrenergic receptor ligands.
Florent Chevillard, Helena Rimmer, Cecilia Betti, Els Pardon, Steven Ballet, Niek van Hilten, Jan Steyaert, Wibke E. Diederich, Peter Kolb
J. Med. Chem. 2018, 61, 1118-1129. [pdf] [Comment @ Practical Fragments]
36 The allosteric site regulates the voltage sensitivity of muscarinic receptors
Annika Hoppe, Maria Martí-Solano, Matthäus Drabek, Moritz Bünemann, Peter Kolb, Andreas Rinne
Cell Signal. 2017, 42, 114-126. [pdf]
full list

Lab members

Florent Chevillard [former Postdoc]
Matthäus Drabek [Graduate Student]
Anja Flöser [Graduate Student]
Peter Kolb [Principal Investigator]
Maria Martí-Solano [former Postdoc]
Ricarda Nagel [Student Researcher]
Julius Perschel [Student Researcher]
Magdalena Scharf [Graduate Student]
Corey Taylor [Graduate Student]
Niek van Hilten [former Master Student]
Not in picture:
Leen Ghanem [Student Researcher]
Torben Gutermuth [Student Researcher]
Lydia Hartleben [Assistant]
Stefania Monteleone [Postdoc]
Susanne Roth [Guest Scientist]

Teaching

We are involved in lectures and lab courses in Pharmaceutical Chemistry. Moreover, we accept students in the Chemistry and Pharmacy curricula for internships. Students with a keen interest in computation, chemistry, and biochemistry and their application to pharmaceutical questions are accepted for B.Sc., M.Sc., and Ph.D. theses (see also below, "Joining the lab").


Scubidoo


PrenDB


Daim – a program to generate fragments


Joining the Lab




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