kolblab.org

Kolb Lab Heisenberg DFG

The Kolb Lab is located at the Department of Pharmaceutical Chemistry at Philipps-Universität Marburg.
We are a member lab of SYNMIKRO
and DRUID.



The lab was deeply involved in COST Action CM1207 "GLISTEN: GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network"
and part of SynChemBio.
The lab started through the generous funding provided within the DFG's Emmy Noether Programme. Emmy Noether DFG
[en][de]

Research interests

Docking
Word cloud generated with WordClouds.com from publication abstracts. Thanks to Xavier Deupi for the idea!

Small molecules are frequently used both in Nature and therapeutically to modulate the activity of the protein they bind to. Yet, many aspects of small-molecule:protein interactions are surprisingly poorly understood. For instance, ligand polypharmacology, i.e. binding to multiple proteins, often comes as a surprise, although it is frequently precisely the reason for a drug's efficacy or its side effects. On the protein side, a point mutation in the binding site, although only a small change, can abolish drug binding, leading to resistance. Thus, it is highly relevant to develop a comprehensive understanding of small-molecule:protein interaction profiles in molecular detail and correlate these profiles with signaling and metabolic pathways.

Our main tool is small molecule docking, but we also use chemoinformatic approaches and molecular dynamics. The research spans method development, basic research and applications. Currently the investigations deal with kinases and G protein-coupled receptors (GPCRs).


Publications

Most recent:
36 The allosteric site regulates the voltage sensitivity of muscarinic receptors
Annika Hoppe, Maria Martí-Solano, Matthäus Drabek, Moritz Bünemann, Peter Kolb, Andreas Rinne
Cell Signal. 2017, 42, 114-126. [pdf]
35 Identification and in silico structural analysis of Gallus gallus Protein Arginine Methyltransferase 4 (PRMT4)
Hannah Berberich, Felix Terwesten, Sinja Rakow, Peeyush Sahu, Caroline Bouchard, Sjaak Philipsen, Peter Kolb, Uta-Maria Bauer
FEBS Open Bio 2017, accepted. [pdf]
34 An open source pharma roadmap
Manica Balasegaram, Peter Kolb, John McKew, Jaykumar Menon, Piero Olliaro, Tomasz Sablinski, Zakir Thomas, Matthew H. Todd, Els Torreele, John Wilbanks
PLOS Med 2017, 14, e1002276. [pdf][essay]
full list

Lab members

Florent Chevillard [Postdoc]
Matthäus Drabek [Graduate Student]
Anja Flöser [Graduate Student]
Peter Kolb [Principal Investigator]
Maria Martí-Solano [former Postdoc]
Ricarda Nagel [Student Researcher]
Julius Perschel [Student Researcher]
Magdalena Scharf [Graduate Student]
Corey Taylor [Graduate Student]
Niek van Hilten [former Master Student]
Not in picture:
Lydia Hartleben [Assistant]
Stefania Monteleone [Postdoc]
Maria Giovanna Papadopoulos [Master Student]
Susanne Roth [Guest Scientist]

Teaching

We are involved in basic lectures and lab courses in Pharmaceutical Chemistry. Moreover, we accept students in the Chemistry and Pharmacy curricula for internships.

Scubidoo


PrenDB


Daim – a program to generate fragments


Joining the Lab




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