|The Kolb Lab is located at the Department of Pharmaceutical Chemistry at Philipps-Universität Marburg.|
|We are a member lab of SYNMIKRO,|
|the transregional collaborative research centre 81 (TRR81),|
|The lab was deeply involved in COST Action CM1207 "GLISTEN: GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network"|
|and part of SynChemBio.|
|The lab started through the generous funding provided within the DFG's Emmy Noether Programme.|
Word cloud generated with WordClouds.com from publication abstracts. Thanks to Xavier Deupi for the idea!
Small molecules are frequently used both in Nature and therapeutically to modulate the activity of the protein they bind to. Yet, many aspects of small-molecule:protein interactions are surprisingly poorly understood. For instance, ligand polypharmacology, i.e. binding to multiple proteins, often comes as a surprise, although it is frequently precisely the reason for a drug's efficacy or its side effects. On the protein side, a point mutation in the binding site, although only a small change, can abolish drug binding, leading to resistance. Thus, it is highly relevant to develop a comprehensive understanding of small-molecule:protein interaction profiles in molecular detail and correlate these profiles with signaling and metabolic pathways.
Our main tool is small molecule docking, but we also use chemoinformatic approaches and molecular dynamics. The research spans method development, basic research and applications. Currently the investigations deal with kinases and G protein-coupled receptors (GPCRs).
Nanobody-enabled reverse pharmacology on GPCRs.
Angew. Chem. Int. Ed. 2018, 57, 5292-5295. [pdf] [Comment @ In the pipeline]
Binding-site compatible fragment growing applied to the design of β2-adrenergic receptor ligands.
J. Med. Chem. 2018, 61, 1118-1129. [pdf] [Comment @ Practical Fragments]
The allosteric site regulates the voltage sensitivity of muscarinic receptors
Cell Signal. 2017, 42, 114-126. [pdf]
|Matthäus Drabek||[Graduate Student]|
|Anja Flöser||[Graduate Student]|
|Leen Ghanem||[Student Researcher]|
|Torben Gutermuth||[former Student Researcher]|
|Peter Kolb||[Principal Investigator]|
|Magdalena Scharf||[Graduate Student]|
|Corey Taylor||[Graduate Student]|
|Not in picture:|
|Jonas Kammertöns||[Student Researcher]|
|Ricarda Nagel||[Student Researcher]|
|Maria Giovanna Papadopoulos||[Graduate Student]|
|Julius Perschel||[Student Researcher]|
|Susanne Roth||[Guest Scientist]|
We are involved in lectures and lab courses in Pharmaceutical Chemistry. Moreover, we accept students in the Chemistry and Pharmacy curricula for internships. Students with a keen interest in computation, chemistry, and biochemistry and their application to pharmaceutical questions are accepted for B.Sc., M.Sc., and Ph.D. theses (see also below, "Joining the lab").
We are developing and maintaining DAIM (Decomposition And Identification of Molecules), a program for fragment generation in the context of fragment-based docking and analysis of molecule libraries. For more information and potential other uses of DAIM see the manual or reference . We are always happy about bug reports, but please consider reading this how-to by Simon Tatham before.
On September 7, 2009 DAIM 5.3 has been released. The update contains several improvements and allows more user choices with respect to the bonds that DAIM cuts. Essentially, it is now possible to override all of the default unbreakable bond definitions. To obtain it, please go to the download page.